This edited volume compiles a set of papers that present various applications of spatial analysis, both traditional and contemporary, on diverse subjects in a wide range of contexts. The volume is dedicated to the memory of the late Professor Pavlos Kanaroglou, McMaster University, Canada, who greatly contributed to scientific and applied research on spatial analysis. In his honor, the book offers a selection of various spatial analysis approaches to the study of contemporary urban transportation, land use, and air pollution issues. The first part of the book discusses selected general issues in spatial analysis; ontologies, agent-based modelling and accessibility analysis. The second part deals with urban transportation analysis and modelling issues; agent-based activity/travel microsimulation, bottleneck models, public transit use, freight transport and connected automated vehicles impact assessment. Part three focuses on integrated land use and transport analysis, discussing the land value impacts of public transport infrastructure, the role of transport provision on business evolution and commute distance considerations in urban relocation. The fourth part, on travel-related air pollution analysis, presents the development of a geo-information software for mapping Aerosol Optical Thickness in urban environments and the development of a neighborhood level, real time, internet-enabled, air pollution map in the Canadian urban context. This book will appeal to academics, researchers, graduate students, consultants, and practitioners working on topics related to spatial analysis, land use and transport analysis, planning and decision making, and air pollution studies.